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#1 2018-05-15 12:32:39


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SAN FRANCISCO Jonathan Quick Jersey Sale , May 7 (Xinhua) -- A group of researchers hasidentified the first "high-confidence" risk gene for Tourettedisorder, also known as Tourette Syndrome, as well as three otherprobable risk genes.

Tourette disorder afflicts as many as one person in a hundredworldwide with potentially disabling symptoms including involuntarymotor and vocal tics. Treatments had only limited effectiveness, inpart because the genetics underlying the disorder have remainedlargely a mystery.

Published online in Neuron on May 3, the new findings are a stepforward in understanding the biology of the disorder and in thesearch for better treatments Dustin Brown Jersey Sale , said the researchers at theUniversity of California, San Francisco, Rutgers University,Massachusetts General Hospital, the University of Florida and YaleSchool of Medicineare.

The researchers used an approach that Matthew State Anze Kopitar Jersey Sale , chair ofthe Department of Psychiatry at UCSF and a co-senior author on thepaper, and his colleagues have pioneered in studies of the geneticbasis of autism spectrum disorders.

They compared the protein-coding regions of the genomes ofchildren with Tourette disorder to the genomes of their parents toidentify so-called de novo variants, namely rare genetic mutationsthat are not inherited from parents, but rather occur spontaneouslyat conception. De novo variants often have stronger biologicaleffects than inherited variants passed from generation togeneration, said Jeremy Willsey Drew Doughty Jersey Sale , an assistant professor ofpsychiatry at UCSF and co-lead author of the paper.

"We study de novo variants even though they are rare becausethey generally have more extreme effects than inherited mutationsand can provide us much information about the underlying causes ofa disease," Willsey explained.

The team analyzed genomic data from 311 "trios" -- children withTourette disorder and their parents, most of whom were unaffectedby the disorder -- collected by the Tourette InternationalCollaborative Genetics group (TIC Genetics), and found strongevidence that de novo variants can play a significant role intriggering the disorder.

To be certain of what they were seeing, the team conducted areplication study in 173 trios from the Tourette Association ofAmerica International Consortium for Genetics (TAAICG) Jonathan Quick Kings Jersey , and foundthe same results.

They then combined the genetic data from the TIC Genetics andTAAICG cohorts, and the resulting dataset allowed them to zero inon four genes expressed in the brain in which de novo variants weresignificantly associated with the disorder.

The analysis identified variants of the gene WWC1, also calledKIBRA, which is involved in brain development, memory Dustin Brown Kings Jersey , and thebrain's response to the hormone estrogen, as having a greater than90 percent probability of contributing to Tourette disorder. Threeother genes, FN1, CELSR3 and NIPBL were flagged as having at least70 percent probability of contributing to the disorder.

"These findings show that Tourette disorder has same pathforward, which means there is a very bright future forunderstanding genetics of the disorder Anze Kopitar Kings Jersey ," State was quoted as sayingin a news release from UCSF. "The very first study I did as ageneticist was of Tourette disorder, so this has been a 20-yearodyssey. It is deeply gratifying to see this long-term effortacross multiple sites and countries lead to real progress."Enditem

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Foreign Ministry spokesperson Geng Shuang (Photo source: fmprc.gov)

BEIJING, Dec. 8 (Xinhua) -- China said Friday that as parties directly involved in the Korean Peninsula nuclear issue Drew Doughty Kings Jersey , the Democratic People's Republic of Korea (DPRK) and the United States should solve their problems through talks and dialogue.

"China always maintains that the Korean Peninsula nuclear issue is a security issue in essence, and the core is the contradiction between the DPRK and the United States," said Chinese Foreign Ministry spokesperson Geng Shuang.

Geng was commenting on Russian Foreign Minister Sergei Lavrov's recent remarks that he had passed a message to the U.S. side that the DPRK was open to direct talks with the United States.

Geng said that China has been making efforts for the United States and the DPRK to solve their differences through talks.

He said that China also welcomes other parties, including Russia, to make efforts to bring the Korean peninsula nuclear issue back to dialogue and consultation as soon as possible.

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